avery's medical-site.info - Ebook download as PDF File .pdf), Text File .txt) or read book online. Avery's Neonatology: Pathophysiology and Management of the Newborn. Home · Avery's Neonatology: Pathophysiology and Management of the Newborn. Avery's Neonatology: Pathophysiology and Management of the Newborn. Avery's Neonatology: Pathophysiology and Management of the Newborn View PDF.
|Language:||English, Spanish, Arabic|
|Genre:||Fiction & Literature|
|Distribution:||Free* [*Register to download]|
Medical Books PDF · April 24, ·. Avery's Diseases of the Newborn 10th Edition Avery's Diseases of the Newborn 10th Edition Covering the. Manage newborns effectively through an accurate understanding of their pathophysiology with Avery's Neonatology! Originally authored by Dr. Gordon B. Avery. download Avery's Neonatology: Pathophysiology and Management of the Newborn ( Avery's Neonatology Pathophusiology and Management of the Newborn): Read 4.
Only 1 month after she began her training, a routine tuberculin skin test that was positive and a small upper lobe infiltrate on a chest radiograph consistent with tuberculosis prompted a course of antibiotics and a prescription for 6 months of bed rest. During this period, questions about her own treatment spurred her quest for more knowledge of respiratory physiology. Returning to her pediatric residency at Johns Hopkins, Mel cared for many premature infants with a lung condition then called hyaline membrane disease HMD , and now known as RDS.
Nearly half of the affected infants died, usually in the first 3 or 4 days, with pathology characterized by atelectasis and hyaline membranes 2. Infants who survived the first few days typically made a complete recovery.
Mel wanted to learn more about the lungs of newborn infants, especially those with HMD. In , following her residency, she moved to Boston to study respiratory physiology with Jere Mead in the Department of Physiology at the Harvard School of Public Health and to learn more about newborn infants from the pediatrician and physiologist Clement Smith who worked across the street at the Boston Lying-In Hospital. Military funding targeted at chemical warfare, especially the effects of nerve gas on the lung, supported many laboratories, including those of Jere Mead, who was studying pulmonary edema, and John Clements, who was interested in surface properties of lung extracts.
Clements had modified a surface balance in order to measure changes in surface tension with changes in area, as occurs during breathing. He found that surface tension of the lung extracts was high when the area was large, corresponding to higher lung volumes, and very low when the area was small, similar to low lung volumes 3. This was due to a saline extractable surface-active material at the alveolar air interface that he named pulmonary surfactant. Mel visited Clements in Maryland soon after his publication to learn his techniques.
Their observations led to their landmark publication 4.
Using the modified surface balance, Avery and Mead measured the lowest surface tension obtained with compression of lung extracts from infants who died of HMD and infants who died of other causes. They found low values in lung extracts from the larger infants without HMD, similar to older children or adults, and high values in infants who died with HMD and in the smallest infants.
They concluded that HMD is caused by the absence or delayed appearance of a substance that, when present, would result in a low surface tension at low lung volume and thus prevent alveolar collapse.
In the s, Dr. Tetsuro Fujiwara studied surfactant biology with Forrest Adams in Los Angeles before he returned to Japan to continue his study of experimental surfactant replacement. Hearing about his work, Mel visited Fujiwara in Japan in At the time, he was working with a pharmaceutical company to develop an artificial surfactant from bovine lungs.
He subsequently performed the first study of surfactant replacement in human infants, reported the next year 5. Mel returned to Boston to help plan a randomized trial of surfactant replacement in the US, using the product characterized by Fujiwara 6.
Pathophysiology and management of the newborn. Philadelphia: Lippincott William Wilkins.
Google Scholar 2. Klein JO. Bacterial sepsis and meningitis. Infectious Diseases of Fetus and Newborn Infant. Google Scholar 3. Dear P.
Neonatal infections: Infections in the newborn. In: Rinnie JM editor. Elsevier Churchill Livingstone; Google Scholar 4. Patterns of use of antibiotics in two newborn nurseries.
N Engl J Med. Early diagnosis of neonatal sepsis.
Residents Handbook of Neonatology. The Newborn Vampire.
Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, 2nd Edition. Color Atlas of Pathophysiology. Heart Physiology and Pathophysiology. Nutrition Therapy and Pathophysiology. Handbook of Pathophysiology. Electrical Trauma: The Pathophysiology, Manifestations and Clinical Management. Atlas of Procedures in Neonatology. Cellulite Pathophysiology and Treatment. Essentials of Pathophysiology.