Editorial Reviews. Review. FIVE STARS FROM DOODY'S REVIEW SERVICE! Entering its fifth decade, this book has been used in conjunction with Dr. West's. PDF | On Oct 1, , Nicholas Lees and others published Respiratory Physiology. massive void of knowledge as regards ventilation physiology produced the. emergence of respiratory physiology  West, J.B. and Dollery, C.T. (). [John B West; Andrew Luks] -- West's Respiratory Physiology: The Essentials is the gold standard text for learning respiratory physiology quickly and easily.
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Rewire Your Brain is meant to be a practical resource book that describes how. would die Rewire Your Brain: Think Your. Lectures in Respiratory PhysiologyJohn B. West MD, PhD. Jump to A description of the lectures and why they were developed can be seen here PDF. Respiratory Physiology: The Essentials,. 7th edition. John B West MD PhD DSc. Philadelphia: Lippincott, Williams, &. Wilkins. Soft cover, illustrated,
The diameter of a capillary segment is about 7 to 10 mm, just large enough for a red blood cell. Alveolar walls are not often seen face on, as in Figure The usual, thin microscopic cross section Figure shows the red blood cells in the capillaries and emphasizes the enormous exposure of blood to alveolar gas, with only the thin blood-gas barrier intervening compare Figure The extreme thinness of the blood-gas barrier means that the capillaries are easily damaged.
The capillaries then leak plasma and even red blood cells into the alveolar spaces. The pulmonary artery receives the whole output of the right heart, but the resistance of the pulmonary circuit is astonishingly small.
Figure View of an alveolar wall in the frog showing the dense network of capillaries.
A small artery leftt and vein rightt can also be seen. The individual capillary segments are so short that the blood forms an almost continuous sheet.
Microscopic section of dog lung showing capillaries in the alveolar walls. This section was prepared from lung that was rapidly frozen while being perfused.
Each red blood cell spends about 0. The lung has an additional blood system, the bronchial circulation that supplies the conducting airways down to about the terminal bronchioles. Some of this blood is carried away from the lung via the pulmonary veins, and some enters the systemic circulation. Such a structure is inherently unstable.
Because of the surface tension of the liquid lining the alveoli, relatively large forces develop that tend to collapse alveoli. Fortunately, some of the cells lining the alveoli secrete a material called surfactantt that dramatically lowers the surface tension of the alveolar lining layer see Chapter 7. As a consequence, the stability of the alveoli is enormously increased, although collapse of small air spaces is always a potential problem and frequently occurs in disease.
Various mechanisms for dealing with inhaled particles have been developed see Chapter 9. Smaller particles that deposit in the conducting airways are removed by a moving staircase of mucus that continually sweeps debris up to the epiglottis, where it is swallowed.
The mucus, secreted by mucous glands and also by goblet cells in the bronchial walls, is propelled by millions of tiny cilia, which move rhythmically under normal conditions but are paralyzed by some inhaled toxins. The alveoli have no cilia, and particles that deposit there are engulfed by large wandering cells called macrophages. The blood-gas barrier is extremely thin with a very large area, making it ideal for gas exchange by passive diffusion.
The conducting airways extend to the terminal bronchioles, with a total volume of about ml. All the gas exchange occurs in the respiratory zone, which has a volume of about 2.
The pulmonary capillaries occupy a huge area of the alveolar wall, and a red cell spends about 0. Concerning the blood-gas barrier of the human lung, The thinnest part of the blood-gas barrier has a thickness of about 3 mm.
The total area of the blood-gas barrier is about 1 square meter. If the pressure in the capillaries rises to unphysiologically high levels, the blood-gas barrier can be damaged. Oxygen crosses the blood-gas barrier by active transport. When oxygen moves through the thin side of the blood-gas barrier from the alveolar gas to the hemoglobin of the red blood cell, it traverses the following layers in order: A.
Epithelial cell, surfactant, interstitium, endothelial cell, plasma, red cell membrane. Some of the chapters are personal accounts of the development of respiratory physiology as observed by the author Covers aspects such as morphology, gas exchange and blood flow, mechanics, control of ventilation, and comparative physiology Show all benefits.
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About this book Present-day respiratory physiology stems largely from the explosion of ideas which took place during and after World War II. Show all.
Pages Lung Surface Tension and Surfactant: Rhythm Generation Euler, Curt Pages Airway and Pulmonary Afferents and Reflexes: A Historical Survey Widdicombe, John et al. Marsh Pages Show next xx.
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